At the year of 1968, there was performance of doctors who 1st did successful transplantation of bone marrow. The bone marrow has somatic stem cells which produces various cell types which make our blood. It is routinely transplanted for treating variety of bone marrow and blood diseases, immune disorders and blood cancers.
Few things to know about Stem Cell Therapy:
Presently, very few treatments of stem cells are proved to be effective and safe. You will lose something if you go for other unproven treatments. Different stem cell type serves different body purposes. Science behind disease must match science behind treatment. Cells from patients own body are not safe automatically when conducted treatments. Testimonials of patients and different marketing being provided by centres of clinics might be misleading. By this stem cell therapy science can become medicine that is designed for maximizing effectiveness and minimizing harm.
Somatic Stem Cell Therapy: By Usage of Bone Marrow Transplantation for Curing Leukemia:
Leukemia is cancer of WBC (white blood cells) or leucocytes. Alike different blood cells, WBCs develop from somatic stem cells. Leucocytes that are mature have to be released to stream of blood where they conduct fighting off body infections. Leukemia is caused when leucocytes function and begin growing abnormally thereby becoming cancerous. Abnormal cells do no fight infection and they start interfering with organ’s functions.
Treatment successfully of leukemia has factors of dependence on being rid of leucocytes that are abnormal in patient in turn allowing growth of ones that are healthy in its place. For doing this 1 way is chemotherapy. This uses drugs potent for killing and targeting abnormal cells. When chemotherapy does not suffice doctors go for transplantation of bone marrow.
In bone marrow transplantation, stem cells from patient bone marrow are replaced with matching healthy donor. All patient abnormal leucocytes and bone marrow existing is 1st killed by usage of radiation and chemotherapy combination. Next donor sample bone marrow that contains stem cells that are healthy is being introduced to blood stream of patient. If successful transplantation is done stem cell migrates to bone marrow of patient and then they begin producing healthy new leucocytes thereby replacing abnormal cells. New studies reveals that stem cells of bone marrow has ability of differentiating cell types which form tissues outside blood like muscle and liver. Scientist explores new uses of stem cells going beyond blood diseases.
Blood Stem Cells Peripheral: Whilst numerous stem cell of blood reside in bone marrow, few are present in blood stream. These PBSCs (peripheral blood stem cells) are used like stem cells of bone marrow for treating leukemia, other blood disorders and other cancers. As they are got from blood drawn, PBSCs have easy collection when compared to stem cells of bone marrow because they are extracted from bones inside present. Therefore these PBSCs are less invasive option of treatment than stem cells of bone marrow. PBSCs are few in blood stream. So collection of enough for performing transplantation may become a challenging factor.
Blood Stem Cells of Umbilical Cord: Infants new-born do not need umbilical cords. Therefore these were discarded traditionally as birth process by-product. But recently, studies revealed that blood found in umbilical cord is rich in stem cells. This is proven very useful in treatment of same health problem types as like that treated by usage of stem cells of bone marrow and PBSCs.
Blood Stem Cells of umbilical cord transplantation are lesser prone to factors of rejection when compared to PBSCs or bone marrow. This is due to fact that cells are not developed recognition features and attack by immune system of recipient. As because blood of umbilical cord lacks immune cells that are well-developed, there are fewer chances of transplanted cell attacking recipient body.