Category Archives: Medical Science

Scope of Digital Genome Technology

Digital Genome Technology is one amongst 10 important technologies of 2015 as highlighted by World Economic Forum’s Meta-Council. Whilst 1st sequencing of DNA base pairs numbered 3.2 billion which makes human genome took a lot of time and priced tens of millions of dollars, presently genome is digitized and sequenced in minutes and priced few 100 dollars. Results are delivered to laptop on USB stick and shared easily by internet. Cheap and rapid ability of determining a person’s make-up genetics uniquely and promise healthcare effectively and more personalized revolution.

Most of a person’ health challenges from cancer to health disease have component of genetic. Cancer is described best as genome disease. With help of digitization, doctors make decisions regarding cancer treatment of patient and get being informed about genetic make-up of tumour. particularly this new technology and its knowledge makes medicine precision a reality and enables high targeted therapy development which offers potential of treatment outcomes improvement for those patients who are undergoing cancer treatment.

Digital genome of a person is to be safeguarded for purpose of privacy alike all other personal information. Genomic profiling personally have challenges raised regarding as to how people have response of clear understanding of genetic disease risk and how insurance companies or employers may desire to use and access information. Advantages outweigh risks because targeted treatments and individualized therapies are developed to create potentialities application for those diseases which are assisted by DNA changes.

Oncology: Research of cancer is conducted typically by usage of biopsies stored in known format of Formalin-Fixed Paraffin-Embedded (FFPE) that subsequently complicates genetic material analysis. Amplification-free robust chemistry allow research for measuring changes subtly in activity of genome in very small samples of FFPE with little degradation performance as compared to fresh tissue analysis. This is an important benefit made by Analysis System for researchers of cancer worldwide.

Translational Research Pathway-based: Analysis System has optimized biological research pathway based to enable researchers for analysing interaction amongst genes numbered in hundreds’ which mediate pathways biologically. System is useful particularly for complex validation of genes networks which helps in predicting and characterizing states of disease for enabling medicines and diagnostics development specifically designed for treatment of patients with some profiles that are genomic.

Molecular Dx: Advancement in research of genome is revolution driven in medicine personalized which accelerates patient care’s innovation. Diagnostic tests genomic-based have demonstrations of ability for identifying genetic hallmark changes which drives numerous diseases like cancer and others. By precision leveraging, mobility and reproducibility of analysis system there is empowerment of local centres in achieving diagnostic clarity level available only previously by means of central lab. New approaches for complex gnome analysis transforms present paradigm by making personalized comprehensive diagnosis that is accessible to worldwide patients.

In secret deep bunker in Swiss Alps researchers of Europe have created and deposited technology of digital genome which provides blueprint for generations of future for reading data being stored by usage of technology that is defunct. It has been getting accompaniment from security guards burly in black uniforms. Scientists carry time capsule by means of labyrinth of 5 security zones and tunnels to vault near slopes of Gstaad that is a resort.

Box is sealed. It contained key for unpicking digital formats defunct. Box is locked away for next century’s quarter behind 3 and half tonne strong door enough for resisting attack nuclear at storage facility of data that is called Swiss Fort Knox. Capsule is 4 year culmination “Planets” project that draws on expertise of Europe libraries 16 in number, research and archives institutions for preserving digital assets of world as software and hardware is being superseded at pace that is blistering.

Stem Cell Therapy, Advantages and Uses

At the year of 1968, there was performance of doctors who 1st did successful transplantation of bone marrow. The bone marrow has somatic stem cells which produces various cell types which make our blood. It is routinely transplanted for treating variety of bone marrow and blood diseases, immune disorders and blood cancers.

Few things to know about Stem Cell Therapy:

Presently, very few treatments of stem cells are proved to be effective and safe. You will lose something if you go for other unproven treatments. Different stem cell type serves different body purposes. Science behind disease must match science behind treatment. Cells from patients own body are not safe automatically when conducted treatments. Testimonials of patients and different marketing being provided by centres of clinics might be misleading. By this stem cell therapy science can become medicine that is designed for maximizing effectiveness and minimizing harm.

Somatic Stem Cell Therapy: By Usage of Bone Marrow Transplantation for Curing Leukemia:

Leukemia is cancer of WBC (white blood cells) or leucocytes. Alike different blood cells, WBCs develop from somatic stem cells. Leucocytes that are mature have to be released to stream of blood where they conduct fighting off body infections. Leukemia is caused when leucocytes function and begin growing abnormally thereby becoming cancerous. Abnormal cells do no fight infection and they start interfering with organ’s functions.

Treatment successfully of leukemia has factors of dependence on being rid of leucocytes that are abnormal in patient in turn allowing growth of ones that are healthy in its place. For doing this 1 way is chemotherapy. This uses drugs potent for killing and targeting abnormal cells. When chemotherapy does not suffice doctors go for transplantation of bone marrow.

In bone marrow transplantation, stem cells from patient bone marrow are replaced with matching healthy donor. All patient abnormal leucocytes and bone marrow existing is 1st killed by usage of radiation and chemotherapy combination. Next donor sample bone marrow that contains stem cells that are healthy is being introduced to blood stream of patient. If successful transplantation is done stem cell migrates to bone marrow of patient and then they begin producing healthy new leucocytes thereby replacing abnormal cells. New studies reveals that stem cells of bone marrow has ability of differentiating cell types which form tissues outside blood like muscle and liver. Scientist explores new uses of stem cells going beyond blood diseases.

Blood Stem Cells Peripheral: Whilst numerous stem cell of blood reside in bone marrow, few are present in blood stream. These PBSCs (peripheral blood stem cells) are used like stem cells of bone marrow for treating leukemia, other blood disorders and other cancers.  As they are got from blood drawn, PBSCs have easy collection when compared to stem cells of bone marrow because they are extracted from bones inside present. Therefore these PBSCs are less invasive option of treatment than stem cells of bone marrow. PBSCs are few in blood stream. So collection of enough for performing transplantation may become a challenging factor.

Blood Stem Cells of Umbilical Cord: Infants new-born do not need umbilical cords. Therefore these were discarded traditionally as birth process by-product. But recently, studies revealed that blood found in umbilical cord is rich in stem cells. This is proven very useful in treatment of same health problem types as like that treated by usage of stem cells of bone marrow and PBSCs.

Blood Stem Cells of umbilical cord transplantation are lesser prone to factors of rejection when compared to PBSCs or bone marrow. This is due to fact that cells are not developed recognition features and attack by immune system of recipient. As because blood of umbilical cord lacks immune cells that are well-developed, there are fewer chances of transplanted cell attacking recipient body.


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